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ALS crim

ALS crim
(C) 2013, All Rights Reserved. authorizes the reproduction and use of this image for any educational, noncommercial purpose, so long as the image is not altered and appropriate credit is cited to and to the creator of the image.

This is a myelin-stained section of spinal cord from a patient who had amyotrophic lateral sclerosis (ALS). Symmetrical degeneration of corticospinal axons occurs secondary to degeneration of cerebrocortical motor neurons in ALS. When axons degenerate, myelin will secondarily be lost. The resulting reactive astrocytosis produces a firm scarlike alteration in the lateral (and anterior) corticospinal tracts or "lateral sclerosis".

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