Neurologic Sequellae of Nutritional Deficiencies 02

Topic: Imaging

Created on Saturday, September 22 2007 by jdmiles

Last modified on Saturday, September 22 2007.

 
        A) Folate
 
        B) Cyanocobalamin
 
        C) Vitamin B3
 
        D) Vitamin B1
 
        E) Vitamin C
 

 

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This question was created on September 22, 2007 by jdmiles.
This question was last modified on September 22, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Folate

This answer is incorrect.

This FLAIR MRI shows hyperintensity in the medial thalamic nuclei. This finding is characteristic of both Wernicke encephalopathy and Korsakoff dementia, which are both due to a deficiency of thiamine (vitamin B1).

Vitamin B9 (Folate) deficiency does not typically produce the lesions shown. Folate deficiency leads to anemia, depression, cognitive impairment, and neural tube defects.

  (See References)

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B) Cyanocobalamin

This answer is incorrect.

This FLAIR MRI shows hyperintensity in the medial thalamic nuclei. This finding is characteristic of both Wernicke encephalopathy and Korsakoff dementia, which are both due to a deficiency of thiamine (vitamin B1).

Vitamin B12 (Cyanocobalamin) deficiency does not typically produce the lesions shown. Cyanocobalamin deficiency leads to pernicious anemia and many neurologic problems: peripheral neuropathy, subacute combined degeneration of the spinal cord, psychosis, depression, dementia, and optic neuropathy.

  (See References)

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C) Vitamin B3

This answer is incorrect.

This FLAIR MRI shows hyperintensity in the medial thalamic nuclei. This finding is characteristic of both Wernicke encephalopathy and Korsakoff dementia, which are both due to a deficiency of thiamine (vitamin B1).

Vitamin B3 (Niacin) deficiency does not typically produce the lesions shown. Niacin deficiency leads to pellagra, a condition characterized by the four Ds: Dementia, Dermatitis, Diarrhea, and eventually Death.

  (See References)

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D) Vitamin B1

This answer is correct.

This FLAIR MRI shows hyperintensity in the medial thalamic nuclei. This finding is characteristic of both Wernicke encephalopathy and Korsakoff dementia, which are both due to a deficiency of thiamine (vitamin B1).

  (See References)

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---

E) Vitamin C

This answer is incorrect.

This FLAIR MRI shows hyperintensity in the medial thalamic nuclei. This finding is characteristic of both Wernicke encephalopathy and Korsakoff dementia, which are both due to a deficiency of thiamine (vitamin B1).

Vitamin C deficiency does not typically produce the lesions shown.

  (See References)

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References:

1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York.
2. Rowland, L.P. (Ed) (2000). Merritt's Neurology, 10th Edition. Lippincott Williams & Wilkins, Philadelphia.
3. So, Y.T., and Simon, R.P. (2004). Deficiency diseases of the nervous system. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1693-1708.
4. Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.) (2001). Harrison's Principles of Internal Medicine, 15th Edition. McGraw Hill. New York.

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imaging
Neurologic Sequellae of Nutritional Deficiencies 02
Question ID: 092207213
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/22/2007
Modified: 09/22/2007
Estimated Permutations: 327600