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Progressive supranuclear palsy, dentate nucleus of cerebellum, H. and E. stain x 200

Last updated on Tuesday, April 28 2009 by gliageek

Progressive supranuclear palsy, dentate nucleus of cerebellum, H. and E. stain x 200

In progressive supranuclear palsy, the cerebellar dentate nucleus classically demonstrates "grumose degeneration", characterized by neuronal loss and astrocytosis accompanied by swollen dystrophic axons (an example is present in the upper middle portion of the photograph).

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