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Vanishing white matter disease, H&E stain, 200 X magnification

Last updated on Tuesday, March 24 2009 by gliageek

Vanishing white matter disease, H&E stain, 200 X magnification

Rarefaction of cerebral white matter with axonal spheroids

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Vanishing white matter disease, H&E stain, 200 X magnification, labeled

Vanishing white matter disease, H&E stain, 200 X magnification, labeled
Axonal spheroids are a non-specific marker of axonal damage, caused by swelling in the axon as material transported along the axon accumulates. Two of these swellings are circled in green in this H&E-stained preparation from a person with vanishing white matter disease (VWMD)...

For Comparison, Normal Neuropil

For Comparison, Normal Neuropil
This is an H&E-stained section of normal neuropil. Compare the homogenous pink background in this image to the pale, thready background in the image of VWMD.

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