Glioblastoma multiforme involving cerebellum, H&E stain x 100

Last updated on Friday, April 3 2009 by gliageek

Glioblastoma multiforme involving cerebellum, H&E stain x 100

Similar to cortical invasion, malignant glial tumors of the cerebellum may demonstrate subpial spread quite distant from the main tumor mass.

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Glioblastoma multiforme involving cerebellum, H&E stain x 100, Labeled
This slide shows spread of a glioblastoma to the cerebellum. The diagnosis of GBM is not clearly evident from this slide, but this is from the same patient as the slide showing the necrosis, so the diagnosis is known. The most significant finding in this...

For comparison, normal adult cerebellum
For comparison, here is a sample of normal adult cerebellum. Note the absence of an external granule cell layer, and the abundant Purkinje cells in the Purkinje cell layer.

For comparison, normal neonate cerebellum
For comparison, this is a sample of normal cerebellum from a neonate. Note the external granule cell layer, and the abundant Purkinje cells in the Purkinje cell layer.