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Myelin 09

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Thursday, February 19 2009.


Courtesy of Dr. Mark Cohen
The best diagnosis for this lesion is?

 
        A) Wernicke-Korsakoff syndrome
 
        B) Pontine ischemic encephalopathy
 
        C) Hypotensive brainstem necrosis
 
        D) Focal pontine leukoencephalopathy
 
        E) Central pontine myelinolysis
 

 


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This question was created on February 15, 2009 by gliageek.
This question was last modified on February 19, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Wernicke-Korsakoff syndrome

This answer is incorrect.


Congestive/hemorrhagic lesions surround 4th ventricle.  (See References)

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B) Pontine ischemic encephalopathy

This answer is incorrect.


Patchy infarcts involving basis pontis. Not confluent.   (See References)

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C) Hypotensive brainstem necrosis

This answer is incorrect.


Affects pontine tegmentum, with sparing of basis pontis.  (See References)

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D) Focal pontine leukoencephalopathy

This answer is incorrect.


Now recognized to be part of disseminating or multifocal leukoencephalopathy, FPL comprises focal lesions in the pontine tegmentum composed of swollen, often calcified axons, and myelin loss.   (See References)

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E) Central pontine myelinolysis

This answer is correct.


CPM is a demyelinating/necrotizing lesion felt to result from osmotic stresses produced from over-rapid correction of hyponatremia   (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820) Advertising:
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pathology
Myelin 09
Question ID: 021509118
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/19/2009
Estimated Permutations: 120

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