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the mechanisms of AED action

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Sunday, September 17 2006.

Which of the following statements regarding the mechanisms of AED action is FALSE?

 
        A) Primidone reduces sodium currents.
 
        B) Lamotrigine acts as a glutamate receptor antagonist.
 
        C) Ethosuximide reduces T-Calcium currents.
 
        D) Levetiracetam reduces T-Calcium currents.
 
        E) Gabapentin acts as a glutamate receptor antagonist.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 17, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Primidone reduces sodium currents.

This answer is incorrect.


The statement, "Primidone reduces sodium currents." is true.
Primidone reduces sodium currents, causes an increase of GABA-mediated currents, acts as a glutamate receptor antagonist, and has a mechanism of action which is as yet not known.  (See References)

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B) Lamotrigine acts as a glutamate receptor antagonist.

This answer is incorrect.


The statement, "Lamotrigine acts as a glutamate receptor antagonist." is true.
Lamotrigine reduces sodium currents, causes an increase of GABA-mediated currents, and acts as a glutamate receptor antagonist.  (See References)

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C) Ethosuximide reduces T-Calcium currents.

This answer is incorrect.


The statement, "Ethosuximide reduces T-Calcium currents." is true.
Ethosuximide reduces T-Calcium currents.  (See References)

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D) Levetiracetam reduces T-Calcium currents.

This answer is correct.


The statement, "Levetiracetam reduces T-Calcium currents." is false.
Levetiracetam has a mechanism of action which is as yet not known.  (See References)

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E) Gabapentin acts as a glutamate receptor antagonist.

This answer is incorrect.


The statement, "Gabapentin acts as a glutamate receptor antagonist." is true.
Gabapentin causes an increase of GABA-mediated currents, and acts as a glutamate receptor antagonist.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
the mechanisms of AED action
Question ID: 299569689
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/17/2006
Estimated Permutations: 0

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