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the mechanisms of AED action

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Sunday, September 17 2006.

Which of the following statements regarding the mechanisms of AED action is FALSE?

 
        A) Zonisamide reduces sodium currents.
 
        B) Gabapentin acts as a glutamate receptor antagonist.
 
        C) Phenobarbital has a mechanism of action which is as yet not known.
 
        D) Levetiracetam has a mechanism of action which is as yet not known.
 
        E) Levetiracetam acts as a glutamate receptor antagonist.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 17, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Zonisamide reduces sodium currents.

This answer is incorrect.


The statement, "Zonisamide reduces sodium currents." is true.
Zonisamide reduces sodium currents, and reduces T-Calcium currents.  (See References)

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B) Gabapentin acts as a glutamate receptor antagonist.

This answer is incorrect.


The statement, "Gabapentin acts as a glutamate receptor antagonist." is true.
Gabapentin causes an increase of GABA-mediated currents, and acts as a glutamate receptor antagonist.  (See References)

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C) Phenobarbital has a mechanism of action which is as yet not known.

This answer is incorrect.


The statement, "Phenobarbital has a mechanism of action which is as yet not known." is true.
Phenobarbital reduces sodium currents, causes an increase of GABA-mediated currents, acts as a glutamate receptor antagonist, and has a mechanism of action which is as yet not known.  (See References)

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D) Levetiracetam has a mechanism of action which is as yet not known.

This answer is incorrect.


The statement, "Levetiracetam has a mechanism of action which is as yet not known." is true.
Levetiracetam has a mechanism of action which is as yet not known.  (See References)

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E) Levetiracetam acts as a glutamate receptor antagonist.

This answer is correct.


The statement, "Levetiracetam acts as a glutamate receptor antagonist." is false.
Levetiracetam has a mechanism of action which is as yet not known.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
the mechanisms of AED action
Question ID: 299569689
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/17/2006
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