FrontalCortex, Inc. is a non-profit corporation dedicated to neurology education.

Neurocutaneous Syndromes 02

Topic: Adult

Created on Saturday, February 17 2007 by jdmiles

Last modified on Saturday, February 17 2007.

Which of the following is characteristically associated with neurofibromatosis type 2?

 
        A) Retinal astrocytoma
 
        B) Paucity or absence of cutaneous lesions
 
        C) Malignant transformation of tumors
 
        D) Axillary freckling
 
        E) Shagreen patches
 

 


Back to the question = Go back to the top of the page.
See another question like this one = Reload a different version of this question ().
Click here for a random question = Load a random question from the database.
Clone this question = Use this question as a template to create a totally NEW question.
Rate this question = Enter detailed rating for this question!
Average user rating for this question = 5 = How users like you have rated this question.
This question was created on February 17, 2007 by jdmiles.
This question was last modified on February 17, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) retinal astrocytoma

This answer is incorrect.


Retinal astrocytomas are not characteristic of NF2. They are associated with tuberous sclerosis.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




B) paucity or absence of cutaneous lesions

This answer is correct.


Skin changes, including cafe au lait spots, molluscum fobrosum (cutaneous tumors), and freckling in the axillae and groin, are typical of neurofibromatosis type 1 (NF1), but are not characteristic of NF2.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




C) malignant transformation of tumors

This answer is incorrect.


Patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas have a lifetime risk of about 5% for malignant transformaiton. The common feature of tumors in NF2 is bilateral acoustic Schwannomas, not malignant transfomation.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




D) axillary freckling

This answer is incorrect.


Skin changes, including cafe au lait spots, molluscum fobrosum (cutaneous tumors), and freckling in the axillae and groin, are typical of neurofibromatosis type 1 (NF1), but are not characteristic of NF2.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




E) shagreen patches

This answer is incorrect.


Shagreen patches are not characteristic of NF2. They are associated with tuberous sclerosis.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

References:

1. Neurofibromatosis Fact Sheet, NINDS. NIH Publication No. 06-2126
2. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York. Pp. 1069-1076.
3. Santos, C.C., Miller, V.S., and Roach, E.S. (2004). Neurocutaneous syndromes. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, 4th Edition. Butterworth Heinemann, Philadelphia. Pp. 1867-1900.
Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
adult
Neurocutaneous Syndromes 02
Question ID: 021707088
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 02/17/2007
Modified: 02/17/2007
Estimated Permutations: 491400

User Comments About This Question:

0 user entries
Please log in if you'd like to add a comment.