Antiepileptic Medications 04

Topic: Pharmacology

Created on Friday, September 28 2007 by jdmiles

Last modified on Friday, September 28 2007.

 
        A) Phenobarbital
 
        B) Primidone
 
        C) Ethosuximide
 
        D) Fosphenytoin
 
        E) Carbamazepine
 

 

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This question was created on September 28, 2007 by jdmiles.
This question was last modified on September 28, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Phenobarbital

This answer is incorrect.

Autoinduction does not occur to a clinically relevant degree with phenobarbital.

  (See References)

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B) Primidone

This answer is incorrect.

Autoinduction does not occur to a clinically relevant degree with primidone.  (See References)

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C) Ethosuximide

This answer is incorrect.

Autoinduction does not occur to a clinically relevant degree with ethosuximide.  (See References)

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D) Fosphenytoin

This answer is incorrect.

Autoinduction does not occur to a clinically relevant degree with fosphenytoin.  (See References)

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E) Carbamazepine

This answer is correct.

Autoinduction is important to consider when dosing Carbamazepine.  The dosage required to maintain a therapeutic level in the first few weeks may change significantly after 1-2 months of treatment, when liver metabolism has been induced by the presence of Carbamazepine.

  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
2. Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
3. Ilo E. Leppik, . . Handbooks in Health Care Company (ISBN:1931981574)	Advertising:
4. Trescher, W.H., and Lesser, R.P. (2004). The epilepsies. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1953-1992.
5. McLean, M.J. (2004). Principles of neuropharmacology and therapeutics. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 877-920.

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pharmacology
Antiepileptic Medications 04
Question ID: 092807076
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/28/2007
Modified: 09/28/2007
Estimated Permutations: 163800