Pediatric Epilepsy Syndromes 07
Topic: PediatricCreated on Thursday, October 4 2007 by jdmiles
Last modified on Thursday, October 4 2007.
A 17 year old girl presents after having a generalized tonic-clonic seizure. She has noticed that, when she brushes her teeth or combs her hair in the morning, she occasionally experiences a brief, involuntary jerk in her upper extremities. Past medical history is otherwise unremarkable. There is no family history of seizures. Exam is normal. You obtain an EEG, which reveals occasional generalized bilateral polyspikes and spike wave complexes at 5Hz. Of the following options, which agent is the best choice as a first-line monotherapy treatment?
A) Carbamazepine B) Clonazepam C) No treatment is indicated D) Tiagabine E) Valproate
This question was created on October 04, 2007 by jdmiles.
This question was last modified on October 04, 2007.
ANSWERS AND EXPLANATIONS
A) Carbamazepine
This answer is incorrect.
This child has juvenile myoclonic epilepsy. Carbamazepine is not the preferred first-line agent in the treatment of this syndrome. Carbamazepine may worsen myoclonus if used as monotherapy. ( See References)
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B) Clonazepam
This answer is incorrect.
This child has juvenile myoclonic epilepsy. Clonazepam is not the preferred first-line agent in the treatment of this syndrome. ( See References)
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C) No treatment is indicated
This answer is incorrect.
This child has juvenile myoclonic epilepsy. Untreated, she is likely to continue having seizures. Treatment is indicated, usually for life. ( See References)
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D) Tiagabine
This answer is incorrect.
This child has juvenile myoclonic epilepsy. Tiagabine is not the preferred first-line agent in the treatment of this syndrome. ( See References)
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E) Valproate
This answer is correct.
This child has juvenile myoclonic epilepsy. Valproate is considered the initial treatment of choice. Lamotrigine and topiramate, while not approved by the FDA for this use, are also commonly used as initial monotherapy. ( See References)
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References:
1. Levin, K.H., and Luders, H.O. (Eds.) (2000). Comprehensive Clinical Neurophysiology. W.B. Saunders Company, Philadelphia.
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2. Trescher, W.H., and Lesser, R.P. (2004). The epilepsies. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1953-1992.
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3. Wheless, J.W., Clarke, D.F., and Carpenter, D. (2005). "Treatment of pediatric epilepsy: expert opinion, 2005." J Child Neurol, 20 Suppl 1 S1-56; quiz S59-60. (PMID:16615562)
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4. Murphy, ., and Delanty, . (2000). "Primary Generalized Epilepsies." Curr Treat Options Neurol, 2(6) 527-542. (PMID:11096777)
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5. Gelisse, P., Genton, P., Kuate, C., Pesenti, A., Baldy-Moulinier, M., and Crespel, A. (2004). "Worsening of seizures by oxcarbazepine in juvenile idiopathic generalized epilepsies." Epilepsia, 45(10) 1282-6. (PMID:15461683)
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6. Prasad, A., Kuzniecky, R.I., Knowlton, R.C., Welty, T.E., Martin, R.C., Mendez, M., and Faught, R.E. (2003). "Evolving antiepileptic drug treatment in juvenile myoclonic epilepsy." Arch Neurol, 60(8) 1100-5. (PMID:12925366)
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pediatric
Pediatric Epilepsy Syndromes 07
Question ID: 100407125
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 10/04/2007
Modified: 10/04/2007
Estimated Permutations: 30240
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