Acanthocytes 01

Topic: Pediatric

Created on Sunday, November 9 2008 by jdmiles

Last modified on Sunday, November 9 2008.

 
        A) Hypobetalipoproteinemia
 
        B) Fabry disease
 
        C) Chorea-acanthocytosis
 
        D) Huntington disease
 
        E) Bassen-Kornzweig syndrome
 

 

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This question was created on November 09, 2008 by jdmiles.
This question was last modified on November 09, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Hypobetalipoproteinemia

This answer is incorrect.

Like abetalipoproteinemia, hypobetalipoproteinemia is characterized by neuropathy, ataxia, and acanthocytosis. A hyperkinetic movement disorder is not typical.  (See References)

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B) Fabry disease

This answer is incorrect.

Acanthocytosis is not a characteristic feature of this disorder.  (See References)

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C) chorea-acanthocytosis

This answer is correct.

Neuroacanthocytosis, also called Levine-Critchley syndrome or chorea-acanthocytosis, is a multisystem neurodegenerative disorder.
Characteristic features of this disorder are the presence of acanthocytes in the blood, and a hyperkinetic movement disorder.  (See References)

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D) Huntington disease

This answer is incorrect.

Acanthocytosis is not a characteristic feature of this disorder.  (See References)

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E) Bassen-Kornzweig syndrome

This answer is incorrect.

Abetalipoproteinemia, also called Bassen-Kornzweig syndrome, is a genetic disease with neurologic findings. The presence of acanthocytes in the blood is characteristic of abetalipoproteinemia. However, a hyperkinetic movement disorder is not part of the typical presentation of abetalipoproteinemia. Neuropathy and ataxia are the classic neurologic manifestations of this disease.  (See References)

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References:

1. Rowland, L.P. (Ed) (2000). Merritt's Neurology, 10th Edition. Lippincott Williams & Wilkins, Philadelphia. (ISBN:0683304747)

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pediatric
Acanthocytes 01
Question ID: 110908140
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 11/09/2008
Modified: 11/09/2008
Estimated Permutations: 360