Adverse effects of AEDs 07

Topic: Pharmacology

Created on Saturday, December 8 2007 by jdmiles

Last modified on Saturday, December 8 2007.

 
        A) Hirsutism
 
        B) Depression
 
        C) Hyperactivity
 
        D) Hepatotoxicity
 
        E) Peripheral neuropathy
 

 

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This question was created on December 08, 2007 by jdmiles.
This question was last modified on December 08, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) hirsutism

This answer is incorrect.

Hirsutism is a hallmark side effect of phenytoin, but is less characteristic of valproate.  (See References)

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B) depression

This answer is incorrect.

Depression is a hallmark side effect of vigabatrin, but is less characteristic of valproate.  (See References)

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C) hyperactivity

This answer is incorrect.

Hyperactivity is a hallmark side effect of vigabatrin, but is less characteristic of valproate.  (See References)

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D) hepatotoxicity

This answer is correct.

Side effects of valproate include hyperammonemia, thrombocytopenia, weight gain, hair loss, hepatotoxicity, tremor, and pancreatitis.  (See References)

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E) peripheral neuropathy

This answer is incorrect.

Peripheral neuropathy is a hallmark side effect of phenytoin and barbiturates, but is less characteristic of valproate.  (See References)

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References:

1. Greenwood, R.S. (2000). "Adverse effects of antiepileptic drugs." Epilepsia, 41 Suppl 2 S42-52. (PMID:10885739)

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pharmacology
Adverse effects of AEDs 07
Question ID: 12080707
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/08/2007
Modified: 12/08/2007
Estimated Permutations: 12558000