Limb-Girdle Muscular Dystrophies

Back to "Congenital Muscular Dystrophies"

Limb-Girdle Muscular Dystrophies

Last updated on Saturday, February 7 2009 by jdmiles

Related images:

Calpainopathy, frozen section of muscle, H&E stain x 200.
Calpainopathy is a subtype of Limb-Girdle muscular dystropy. Pathologically, it is characterized by degenerating and regenerating muscle fibers, fibrosis between the muscle fibers, and lobulated type 1 muscle fibers.

Calpainopathy, paraffin-embedded H&E stained section of muscle x 200
Amongst the limb girdle muscular dystrophies, patients with abnormalities in calpain typically demonstrate eosinophilic muscle inflammation in the early stages of the disease process.

Calpainopathy, paraffin-embedded H&E stained section x 400
Note muscle fiber degeneration attended by a mixed inflammatory infiltrate including a significant proportion of eosinophils.

Calpainopathy, paraffin-embedded H&E stained section x 600
Eosinophils are characterized by bilobed nuclei and bright orange granular cytoplasm.