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Kearns-Sayre syndrome, H&E section of substantia nigra x 200

Last updated on Tuesday, April 21 2009 by gliageek

Kearns-Sayre syndrome, H&E section of substantia nigra x 200

Mitochondrial encephalopathies are characterized by symmetric, sharply circumscribed lesions affecting susceptible brain regions. The classic histopathologic features of mitochondrial central nervous system disease include degeneration of neuropil with prominent dilated capillary blood vessels and morphologic preservation of neuronal cell bodies (distinguishing the lesions from simple ischemic necrosis).

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