Inclusion Body Myositis

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Inclusion Body Myositis

Last updated on Wednesday, October 1 2008 by jdmiles

Inclusion body myositis is an inflammatory myopathy.

You can see rimmed vaucoles on trichrome, like in this image

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Related videos:

Inclusion Body Myositis
An overview of inclusion body mysositis. 11 minutes, 33 seconds.

Related images:

Inclusion body myositis, trichrome stain, low-power.
On trichrome stained frozen muscle, vacuoles are also associated with reddish granular material.

Inclusion body myositis, Gomori trichrome stained frozen muscle x 200
On trichrome stained frozen muscle, vacuoles are also associated with reddish granular material.

Inclusion body myositis, SMI-31 immunohistochemical stain x 400
SMI-31 immunohistochemical staining can be performed on paraffin embedded tissue, and highlights abnormal accumulations of paired helical filament tau protein within the muscle fiber nuclei.

Inclusion body myositis, SMI-31 immunohistochemical staining x200
SMI-31 immunohistochemical staining can be performed on paraffin embedded tissue, and highlights abnormal accumulations of paired helical filament tau protein within both cytoplasm and nuclei.

Inclusion body myositis, SMI-31 immunohistochemical staining x400
SMI-31 immunohistochemical staining can be performed on paraffin embedded tissue, and highlights abnormal accumulations of paired helical filament tau protein within both cytoplasm and nuclei.

Inclusion body myositis, Gomori trichrome stain x 200
In addition to highlighting granules associated with the intracytoplasmic inclusions, trichrome staining also demonstrates endomysial fibrosis commonly seen in inclusion body myositis.

Inclusion body myositis, Gomori trichrome stain x400
Occasional fibers demonstrate abundance of granular material. with inconspicuous vacuolization

Inclusion body myositis, H&E stain x200
In addition to the characteristic intracytoplasmic inclusions, inclusion body myositis presents a dystrophic appearance with wide variety in fiber size and shape accompanied by increased endomysial fibrous tissue.

Inclusion body myositis, H&E stain x400
In many cases of inclusion body myositis, rimmed vacuoles are readily appreciated on routine H&E stain sections of frozen muscle. Processing for paraffin embedding dissolves the granules associated with the vacuoles of inclusion body myositis, necessitating...