Pelizaeus Merzbacher disease, Coronal section, Close Up

Last updated on Tuesday, March 24 2009 by gliageek

Pelizaeus Merzbacher disease, Coronal section, Close Up

"Tigroid" demyelination with preservation of subcortical U fibers

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Pelizaeus Merzbacher disease, Coronal section, Close Up, labeled
This image shows a coronal section through a gross brain specimen from someone who had Pelizaeus Merzbacher disease. There is demyelination of the white matter (blue), with sparing of the subcortical U-fibers (green). The demyelinated area (labeled in blue)...

For comparison, Alexander disease
For comparison, here is a coronal section of brain from a person with Alexander disease, showing diffuse loss of white matter without sparing of subcortical U fibers