ATPase - Example of pathological findings

Last updated on Sunday, April 5 2009 by jdmiles

ATPase - Example of pathological findings

This is an ATPase stain of skeletal muscle from a patient with Central Core Disease (CCD). As with many of the inherited structural myopathies, in CCD there is often a predominance of type 1 fibers compared to type 2 fibers. The ATPase-stained image below does not demonstrate any cores, but does highlight the preponderance of type 1 fibers. The absence of cores on ATPase indicates cores are of the "structured" type.

In this particular example, there is a reddish tint. This is because the laboratory that ran this specimen used an eosin counterstain, which is not usually done.

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ATPase - Example of pathological findings
This is an ATPase stain of skeletal muscle from a patient with central core disease. With this stain, type 2 fibers appear dark red, and type 1 fibers are a lighter pink. Note the predominance of type 1 fibers, which is characteristic of central core disease.