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Myelin 04

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.

Courtesy of Dr. Mark Cohen

This 42 year old male experienced sudden onset of fever, neck stiffness, and seizures. He became comatose and died 3 days later. The best diagnosis is:

A) Acute (Marburg) multiple sclerosis

B) Acute disseminated encephalomyelitis

C) Balo variant of MS

D) Acute hemorrhagic leukoencephalitis

E) Schilder disease

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This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

ANSWERS AND EXPLANATIONS

A) Acute (Marburg) multiple sclerosis

This answer is incorrect.

Lesions more discrete. Not as fulminant (See References)


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B) Acute disseminated encephalomyelitis

This answer is incorrect.

Less fulminant course. Symmetric. Non-hemorrhagic. (See References)


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C) Balo variant of MS

This answer is incorrect.

Concentric plaques (See References)


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D) Acute hemorrhagic leukoencephalitis

This answer is correct.

Hyperacute form of ADEM with fulminant course and high mortality rate. 75% are markedly asymmetric. (See References)


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E) Schilder disease

This answer is incorrect.

Bilateral demyelination affecting children (See References)


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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Myelin 04
Question ID: 021509084
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120