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Neurocutaneous 09

Topic: Pathology

Created on Monday, February 16 2009 by gliageek

Last modified on Monday, February 16 2009.

Courtesy of Dr. Mark Cohen

This infant was born with a large cutaneous pigmented lesion, and these grayish macules in his meninges. Which of the following malformations is most likely to also be found in his brain?

A) Agenesis of corpus callosum

B) Leptomeningeal gliomatosis

C) Dandy-Walker malformation

D) Holoprosencephaly

E) Angiomatosis

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This question was created on February 16, 2009 by gliageek.
This question was last modified on February 16, 2009.

ANSWERS AND EXPLANATIONS

A) Agenesis of corpus callosum

This answer is incorrect.

Though a frequent accompaniment to a wide variety of genetic syndromes, not common in NCM (See References)


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B) Leptomeningeal gliomatosis

This answer is incorrect.

Occasionally encountered in NF-1 (See References)


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C) Dandy-Walker malformation

This answer is correct.

Most frequent developmental abnormality in patients with neurocutaneous melanosis (See References)


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D) Holoprosencephaly

This answer is incorrect.

Trisomy 13 (See References)


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E) Angiomatosis

This answer is incorrect.

Part of Sturge-Weber disease (See References)


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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Neurocutaneous 09
Question ID: 021609122
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/16/2009
Modified: 02/16/2009
Estimated Permutations: 120