antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Carbamazepine must be started at a low dose.
 
        B) Oxcarbazepine causes reduction of sodium currents.
 
        C) Oxcarbazepine is the drug of first choice for patients with absence seizures only.
 
        D) Gabapentin causes increase of GABA-mediated currents.
 
        E) Ethosuximide has no known significant interactions with other AEDs.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Carbamazepine must be started at a low dose.

This answer is incorrect.

The statement, "Carbamazepine must be started at a low dose." is true.
Carbamazepine causes reduction of sodium currents, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, is excreted in breast milk, must be started at a low dose, may exacerbate absence seizures, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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B) Oxcarbazepine causes reduction of sodium currents.

This answer is incorrect.

The statement, "Oxcarbazepine causes reduction of sodium currents." is true.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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C) Oxcarbazepine is the drug of first choice for patients with absence seizures only.

This answer is correct.

The statement, "Oxcarbazepine is the drug of first choice for patients with absence seizures only." is false.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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D) Gabapentin causes increase of GABA-mediated currents.

This answer is incorrect.

The statement, "Gabapentin causes increase of GABA-mediated currents." is true.
Gabapentin causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, and has no known significant interactions with other AEDs.  (See References)

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E) Ethosuximide has no known significant interactions with other AEDs.

This answer is incorrect.

The statement, "Ethosuximide has no known significant interactions with other AEDs." is true.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0