Did you know...
that each question in the question bank can change every time you reload it?

Methotrexate neurotoxicity, H&E

Methotrexate neurotoxicity, H&E
(C) 2009 FrontalCortex.com, All Rights Reserved.
FrontalCortex.com authorizes the reproduction and use of this image for any educational, noncommercial purpose, so long as the image is not altered and appropriate credit is cited to FrontalCortex.com and to the creator of the image.

Axonal spheroids are a non-specific marker of axonal damage. Proximal to the point where an axon has been damaged, the cell body and proximal axon are still functioning, and axonal transport mechanisms are still trying to move molecules and organelles toward the distal end of the neuron. However, this stuff cannot get transported past the site of the injury. The accumulated material builds up, the axon swells, and when cut in cross-section, looks like the red blob indicated by the unnecessarily large green arrow in the image above. Retrograde axonal transport also contributes. These swellings are called axonal spheroids.

<-- Previous Image
Return to the main gallery
Next Image -->

0 user entries
Please log in if you'd like to add a comment.