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Alexander disease, coronal secti


Alexander disease, coronal secti
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FrontalCortex.com authorizes the reproduction and use of this image for any educational, noncommercial purpose, so long as the image is not altered and appropriate credit is cited to FrontalCortex.com and to the creator of the image.

This is a slice of brain from a patient who had Alexander disease. In this disease, there is diffuse loss of white matter. In this image, note how dark the demyelinated white matter appears, especially in contrast to the relatively spared region indicated by the unnecessarily large red arrow. Note also that the subcortical U-fibers (outlined in green) are also demyelinated. This finding can be of diagnostic value when trying to differentiate different leukodystrophies.

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