Glioblastoma multiforme, small c

uploaded on: Apr 04, 2009
by: jdmiles

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Glioblastomas composed predominantly of small undifferentiated glial elements must be distinguished from anaplastic oligodendrogliomas. The presence of necrosis with peripheral palisading of tumor cells is very useful in this regard. Small cell glioblastoma is often demonstrate EGFR amplification. One area of pseudopallisading necrosis is indicated by the unnececessarily large green arrow (arrow points to the necrotic center). Can you find the second area of pseudopallisading necrosis in this image?

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