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Vanishing White matter disease,

Vanishing White matter disease,
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Axonal spheroids are a non-specific marker of axonal damage. Proximal to the point where an axon has been damaged, the cell body and proximal axon are still functioning, and axonal transport mechanisms are still trying to move molecules and organelles toward the distal end of the neuron. However, this stuff cannot get transported past the site of the injury. The accumulated material builds up, the axon swells, and when cut in cross-section, looks like the red blobs circled in green in this image. Retrograde axonal transport also contributes. These swellings are called axonal spheroids.

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