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Clival chordoma, H&E stain x 400

Clival chordoma, H&E stain x 400
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Multi-Vacuolated cells, referred to as physaliferous cells (having the appearance of being filled with soap bubbles), are characteristically present within chordomas. However, similar cells may be seen in adenocarcinomas and/or chondrosarcomas requiring immunohistochemical distinction for diagnosis.

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