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Alexander Disease, H&E stained section of cerebral cortex, 200 X magnification

Last updated on Tuesday, March 24 2009 by gliageek

Alexander Disease, H&E stained section of cerebral cortex, 200 X magnification

Abundant Rosenthal fiber formation demonstrating subpial and perivascular accentuation

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Alexander Disease, H&E stained section of cerebral cortex, 200 X magnification with arrow

Alexander Disease, H&E stained section of cerebral cortex, 200 X magnification with arrow
All these red blobs, like the one indicated by the unnecessarily large green arrow, are Rosenthal fibers. Rosenthal fibers are eosinophilic, intracytoplasmic inclusions seen in reactive tissue, neoplasms like pilocytic astrocytoma, and in Alexander disease...

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