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Methotrexate neurotoxicity, H&E stained section x 100

Last updated on Tuesday, March 24 2009 by gliageek

Methotrexate neurotoxicity, H&E stained section x 100

Multi-Focal necrotizing leukoencephalopathy with axonal spheroids

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Methotrexate neurotoxicity, H&E stained section x 100 with arrow

Methotrexate neurotoxicity, H&E stained section x 100 with arrow
Axonal spheroids are a non-specific marker of axonal damage. Proximal to the point where an axon has been damaged, the cell body and proximal axon are still functioning, and axonal transport mechanisms are still trying to move molecules and organelles toward the distal end of the neuron...

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