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Oligodendroglioma, high power H&E

Last updated on Thursday, April 9 2009 by gliageek

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Oligodendroglioma, high power H&E
This is an H&E stain of an oligodendroglioma. Note the numerous cells with small, dark nuclei, and surrounded by pale cytoplasm. This is what gives the tissue the appearance that is often described as looking like a bunch of fried eggs. Look at the slide of normal neuropil (below) for comparison. Although this fried egg appearance is felt to be classic for oligodendroglioma, it is an artifact of delayed fixation and therefore is not present within intraoperative frozen sections nor within promptly fixed biopsy material.