Gomori Trichrome, showing inclusion bodies

Last updated on Friday, September 26 2008 by jdmiles

Gomori Trichrome, showing inclusion bodies

The Gomori trichrome stain is a beautiful and efficient way to visualize muscular pathology which do not show well on H&E staining. For example, this specimen shows a biopsy of skeletal muscle from a patient with inclusion body myositis (IBM). The trichrome stain allows the visualization of the rimmed vacuoles that are the hallmark of this disease. These vacuoles would be harder to see on H&E.

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IBM trichrome with highlighted rimmed vacuoles
This is a Gomori trichrome stain of skeletal muscle. The patient has inclusion body myositis (IBM). Note that most of the muscle fibers look pretty normal. However, there are a couple of fibers (encircled by the thick red line) which contain numerous rimmed vacuoles...