FrontalCortex, Inc. is a non-profit corporation dedicated to neurology education.

Neurodegen 01

Topic: Anatomy

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Courtesy of Dr. Mark Cohen

The pathologic abnormalities shown here are associated with which of the following mutations?

 
        A) Beta-amyloid precursor protein
 
        B) LRRK2
 
        C) Prion P102L
 
        D) Superoxide dismutase 1
 
        E) Presenilin 1
 

 


Back to the question = Go back to the top of the page.
See another question like this one = Reload a different version of this question ().
Click here for a random question = Load a random question from the database.
Clone this question = Use this question as a template to create a totally NEW question.
Rate this question = Enter detailed rating for this question!
Average user rating for this question = 5 = How users like you have rated this question.
This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) beta-amyloid precursor protein

This answer is incorrect.


Mutations in the B-APP gene result in Lewy body variant of AD  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




B) LRRK2

This answer is incorrect.


LRRK2 mutations are the most common cause familial late onset Parkinson disease  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




C) Prion P102L

This answer is incorrect.


This is the most common mutation in patients with Gerstmann-Straussler-Scheinker disease. GSS shows abundant multicentric amyloid plaques in the cerebral and cerebellar cortices.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




D) superoxide dismutase 1

This answer is incorrect.


SOD1 mutations underlie a small proportion of familial ALS  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




E) Presenilin 1

This answer is correct.


Cotton-wool plaques are typically seen in early-onset familial AD secondary to mutations in presenilin-1  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

 

 

 

References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)Advertising:
Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 5
Please log in if you want to rate questions.

 

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
anatomy
Neurodegen 01
Question ID: 020809087
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

User Comments About This Question: