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Basic Neuropathology 8

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Created on Thursday, February 14 2013 by gliageek

Last modified on Thursday, February 14 2013.


Courtesy of Dr. Mark Cohen
The histopathological abnormalities seen within the cerebellar molecular layer in this high power photomicrographs is most characteristic of which is a following diseases?

 
        A) Alzheimer's disease
 
        B) Rabies encephalitis.
 
        C) Progressive multifocal leukoencephalopathy
 
        D) Parkinson's disease
 
        E) Jakob-Creutzfeldt disease
 

 


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This question was created on February 14, 2013 by gliageek.
This question was last modified on February 14, 2013.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Alzheimer's disease

This answer is incorrect.


Patients with Alzheimer's disease may show immunoreactivity for amyloid within the cerebellar molecular layer, but do not show plaques within the cerebellar granule cell layer. In addition, senile plaques in Alzheimer disease do not show peripheral radiations.  (See References)

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B) Rabies encephalitis.

This answer is incorrect.


In patients with rabies encephalitis, Negri (or lyssa) bodies may be seen within the cytoplasm Of Purkinje cells.  (See References)

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C) Progressive multifocal leukoencephalopathy

This answer is incorrect.


Progressive multifocal leukoencephalopathy is characterized by intranuclear inclusions within astrocytes and oligodendroglial cells.  (See References)

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D) Parkinson's disease

This answer is incorrect.


Lewy bodies are intracytoplasmic inclusions.  (See References)

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E) Jakob-Creutzfeldt disease

This answer is correct.


About 10% of patients with sporadic Jakob-Creutzfeldt disease will show kuru plaques within the cerebellar granule cell layer  (See References)

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References:

1. Krasnianski, A., Schulz-Schaeffer, W.J., Kallenberg, K., Meissner, B., Collie, D.A., Roeber, S., Bartl, M., Heinemann, U., Varges, D., Kretzschmar, H.A., and Zerr, I. (2006). "Clinical findings and diagnostic tests in the MV2 subtype of sporadic CJD." Brain, 129(Pt 9) 2288-96. (PMID:16720682)
2. Sikorska, B., Knight, R., Ironside, J.W., and Liberski, P.P. (2012). "Creutzfeldt-Jakob disease." Adv Exp Med Biol, 724 76-90. (PMID:22411235)
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Basic Neuropathology 8
Question ID: 021413097
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/14/2013
Modified: 02/14/2013
Estimated Permutations: 120

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