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Inclusionology 03

Topic: Imaging

Created on Monday, February 11 2013 by gliageek

Last modified on Monday, February 11 2013.


Courtesy of Dr. Mark Cohen
This section was obtained from the frontal neocortex of a patient with behavioral variant dementia. Which is the following antibodies would react most strongly with the neuronal cytoplasmic inclusion?

 
        A) TDP-43
 
        B) GFAP
 
        C) Tau
 
        D) Alpha-synuclein
 
        E) FUS
 

 


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This question was created on February 11, 2013 by gliageek.
This question was last modified on February 11, 2013.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) TDP-43

This answer is incorrect.


Although inclusions immunoreactive with TDP-43 comprise the most common pathological form of frontotemporal lobar degeneration, The protein is not found within Pick bodies.  (See References)

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B) GFAP

This answer is incorrect.


Glial fibrillary acidic protein is the predominant intermediate filament within astrocytes, but is not present with in neurons.  (See References)

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C) Tau

This answer is correct.


Pick bodies are composed predominantly of cross-linked tau protein  (See References)

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D) Alpha-synuclein

This answer is incorrect.


Alpha-synuclein is the predominant protein found within Lewy bodies, but is not identified within Pick bodies.  (See References)

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E) FUS

This answer is incorrect.


Inclusions immunoreactive with FUS (fused in sarcoma) are found within a subset of patients with frontotemporal lobar degeneration. These patients may demonstrate basophilic intraneuronal inclusions, but not Pick bodies.  (See References)

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References:

1. Dickson, D.W., Kouri, N., Murray, M.E., and Josephs, K.A. (2011). "Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau)." J Mol Neurosci, 45(3) 384-9. (PMID:21720721)
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imaging
Inclusionology 03
Question ID: 021113119
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/11/2013
Modified: 02/11/2013
Estimated Permutations: 120

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