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Basic Neuropathology 6

Topic: Imaging

Created on Monday, February 11 2013 by gliageek

Last modified on Monday, February 11 2013.


Courtesy of Dr. Mark Cohen
These structures are most commonly encountered in?

 
        A) Cockayne disease
 
        B) Glycogen storage disease type IV
 
        C) Meningiomas
 
        D) Normal aging
 
        E) Familial myoclonic epilepsy
 

 


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This question was created on February 11, 2013 by gliageek.
This question was last modified on February 11, 2013.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Cockayne disease

This answer is incorrect.


Basal ganglia calcifications are characteristic of Cockayne disease, but do not show the lamellated appearance of corpora amylacea.  (See References)

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B) Glycogen storage disease type IV

This answer is incorrect.


Although corpora amylacea are one of the cardinal pathological features of glycogen storage disease type IV (Andersen disease, brancher enzyme deficiency), they are rarely encountered as a part of this disease process due to the rarity of this storage disease.  (See References)

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C) Meningiomas

This answer is incorrect.


Although also lamellated, psammoma bodies are more eosinophilic, and are surrounded by tumor cells.  (See References)

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D) Normal aging

This answer is correct.


Corpora amylacea represent in digestible remnants of astrocyte metabolism, and are commonly seen in aged brains.  (See References)

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E) Familial myoclonic epilepsy

This answer is incorrect.


Although morphologically similar, Lafora bodies are located within the cytoplasm of neurons.  (See References)

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References:

1. (2006). "Age-related neuropathology, cognitive decline, and Alzheimer's disease." , 5(1) 1-13. (PMID:16084778)
2. Robitaille, Y., Carpenter, S., Karpati, G., and DiMauro, S.D. (1980). "A distinct form of adult polyglucosan body disease with massive involvement of central and peripheral neuronal processes and astrocytes: a report of four cases and a review of the occurrence of polyglucosan bodies in other conditions such as Lafora's disease and normal ageing." Brain, 103(2) 315-36. (PMID:6249438)
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imaging
Basic Neuropathology 6
Question ID: 021113130
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/11/2013
Modified: 02/11/2013
Estimated Permutations: 120

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