There are 484 questions on various topics in Neurology in the FrontalCortex neurology question bank.

Dementia 02

Topic: Imaging

Created on Thursday, February 22 2007 by jdmiles

Last modified on Thursday, February 22 2007.

A 65 year-old male presents to your office accompanied by his sister, who provides most of the history.
The sister states that for quite some time now, the patient has had more and more trouble remembering things, has been increasingly slow getting around, has complained of a tremor in his hands, has been distressed from seeing people in the room that nobody else sees, has had dramatic fluctuations in his level of arousal, and has complained of stiffness.
Which of the following pathology findings is MOST characteristic of this patient's disease?

A) Inclusions comprised primarily of beta amyloid

B) Bunina bodies

C) Basophilic cytoplasmic inclusions

D) Lewy bodies

E) Basophilic nuclear inclusions

	= Go back to the top of the page.
	= Reload a different version of this question ().
	= Load a random question from the database.
	= Use this question as a template to create a totally NEW question.
	= Enter detailed rating for this question!
Average rating not yet available	= How users like you have rated this question.

This question was created on February 22, 2007 by jdmiles.
This question was last modified on February 22, 2007.

ANSWERS AND EXPLANATIONS

A) inclusions comprised primarily of beta amyloid

This answer is incorrect.

This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions comprised mainly of alpha-synuclein, not beta amyloid. (See References)

					Average rating not yet available
Please log in if you want to rate questions.

B) Bunina bodies

This answer is incorrect.

This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Neuronal aggregates and Bunina bodies are seen in amyotrophic lateral sclerosis. (See References)

					Average rating not yet available
Please log in if you want to rate questions.

C) basophilic cytoplasmic inclusions

This answer is incorrect.

					Average rating not yet available
Please log in if you want to rate questions.

D) Lewy bodies

This answer is correct.

					Average rating not yet available
Please log in if you want to rate questions.

E) basophilic nuclear inclusions

This answer is incorrect.

					Average rating not yet available
Please log in if you want to rate questions.

References:

1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York.
2. DeKosky, S.T., Kaufer, D.I., and Lopez, O.L. (2004). The Dementias. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, 4th Edition. Butterworth Heinemann, Philadelphia. Pp. 1901-1951
3. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier, Philadelphia.

					Average rating not yet available
Please log in if you want to rate questions.

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
imaging
Dementia 02
Question ID: 02220701
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 02/22/2007
Modified: 02/22/2007
Estimated Permutations: 0