Dementia 02
Topic: Imaging
Created on Thursday, February 22 2007 by jdmiles
Last modified on Thursday, February 22 2007.
A 60 year-old female presents to your office accompanied by her boyfriend, who provides most of the history.
The boyfriend states that for quite some time, the patient developed a tremor, has been increasingly forgetful, has fallen several times, occasionally will stare off into space for long periods of time, has had increasing difficulty inititiating movement, and has been seeing visions of beautiful gold butterflies.
Which of the following pathology findings is MOST characteristic of this patient's disease?
A) Inclusions comprised primarily of beta amyloid B) Lewy bodies C) Basophilic cytoplasmic inclusions D) Basophilic nuclear inclusions E) Bunina bodies
This question was created on February 22, 2007 by jdmiles.
This question was last modified on February 22, 2007.
ANSWERS AND EXPLANATIONS
A) inclusions comprised primarily of beta amyloid
This answer is incorrect.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions comprised mainly of alpha-synuclein, not beta amyloid. (
See References)
B) Lewy bodies
This answer is correct.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions which contain alpha-synuclein. (
See References)
C) basophilic cytoplasmic inclusions
This answer is incorrect.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions. (
See References)
D) basophilic nuclear inclusions
This answer is incorrect.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions. (
See References)
E) Bunina bodies
This answer is incorrect.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Neuronal aggregates and Bunina bodies are seen in amyotrophic lateral sclerosis. (
See References)
References:
1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York. | |
2. DeKosky, S.T., Kaufer, D.I., and Lopez, O.L. (2004). The Dementias. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, 4th Edition. Butterworth Heinemann, Philadelphia. Pp. 1901-1951 | |
3. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier, Philadelphia. | |
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imaging
Dementia 02
Question ID: 02220701
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 02/22/2007
Modified: 02/22/2007
Estimated Permutations: 0