Check out the user forums pages.

Dementia 02

Topic: Imaging

Created on Thursday, February 22 2007 by jdmiles

Last modified on Thursday, February 22 2007.

A 60 year-old female presents to your office accompanied by her boyfriend, who provides most of the history.
The boyfriend states that for quite some time, the patient developed a tremor, has been increasingly forgetful, has fallen several times, occasionally will stare off into space for long periods of time, has had increasing difficulty inititiating movement, and has been seeing visions of beautiful gold butterflies.
Which of the following pathology findings is MOST characteristic of this patient's disease?

A) Inclusions comprised primarily of beta amyloid

B) Lewy bodies

C) Basophilic cytoplasmic inclusions

D) Basophilic nuclear inclusions

E) Bunina bodies

	= Go back to the top of the page.
	= Reload a different version of this question ().
	= Load a random question from the database.
	= Use this question as a template to create a totally NEW question.
	= Enter detailed rating for this question!
Average rating not yet available	= How users like you have rated this question.

This question was created on February 22, 2007 by jdmiles.
This question was last modified on February 22, 2007.

ANSWERS AND EXPLANATIONS

A) inclusions comprised primarily of beta amyloid

This answer is incorrect.

This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions comprised mainly of alpha-synuclein, not beta amyloid. (See References)

					Average rating not yet available
Please log in if you want to rate questions.

B) Lewy bodies

This answer is correct.

					Average rating not yet available
Please log in if you want to rate questions.

C) basophilic cytoplasmic inclusions

This answer is incorrect.

					Average rating not yet available
Please log in if you want to rate questions.

D) basophilic nuclear inclusions

This answer is incorrect.

					Average rating not yet available
Please log in if you want to rate questions.

E) Bunina bodies

This answer is incorrect.

This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Neuronal aggregates and Bunina bodies are seen in amyotrophic lateral sclerosis. (See References)

					Average rating not yet available
Please log in if you want to rate questions.

References:

1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York.
2. DeKosky, S.T., Kaufer, D.I., and Lopez, O.L. (2004). The Dementias. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, 4th Edition. Butterworth Heinemann, Philadelphia. Pp. 1901-1951
3. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier, Philadelphia.

					Average rating not yet available
Please log in if you want to rate questions.

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
imaging
Dementia 02
Question ID: 02220701
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 02/22/2007
Modified: 02/22/2007
Estimated Permutations: 0