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Adverse effects of AEDs 08

Topic: Pharmacology

Created on Saturday, December 8 2007 by jdmiles

Last modified on Saturday, December 8 2007.

Which of the following is a hallmark side effect of felbamate?

 
        A) Hepatotoxicity
 
        B) Coarsening of the facies
 
        C) Hyperammonemia
 
        D) Hepatoxicity
 
        E) Dupytren's contractures
 

 


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This question was created on December 08, 2007 by jdmiles.
This question was last modified on December 08, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) hepatotoxicity

This answer is incorrect.


Hepatotoxicity is a hallmark side effect of valproate, but is less characteristic of felbamate.  (See References)

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B) coarsening of the facies

This answer is incorrect.


Coarsening of the facies is a hallmark side effect of phenytoin, but is less characteristic of felbamate.  (See References)

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C) hyperammonemia

This answer is incorrect.


Hyperammonemia is a hallmark side effect of valproate, but is less characteristic of felbamate.  (See References)

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D) hepatoxicity

This answer is correct.


Side effects of felbamate include weight loss, hepatoxicity, insomnia, aplastic anemia, and anorexia.  (See References)

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E) Dupytren's contractures

This answer is incorrect.


Dupytren's contractures is a hallmark side effect of barbiturates, but is less characteristic of felbamate.  (See References)

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References:

1. Greenwood, R.S. (2000). "Adverse effects of antiepileptic drugs." Epilepsia, 41 Suppl 2 S42-52. (PMID:10885739)
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pharmacology
Adverse effects of AEDs 08
Question ID: 12080708
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/08/2007
Modified: 12/08/2007
Estimated Permutations: 12285000

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