antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Diazepam is metabolized primarily in the liver.
 
        B) Diazepam is associated with an increased risk of spina bifida if taken during pregnancy.
 
        C) Clonazepam works via an unknown mechanism.
 
        D) Oxcarbazepine has no known significant drug interactions.
 
        E) Ethosuximide is a glutamate receptor antagonist.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Diazepam is metabolized primarily in the liver.

This answer is correct.

The statement, "Diazepam is metabolized primarily in the liver." is true.
Diazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is metabolized primarily in the liver, is approved as adjunct therapy only, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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B) Diazepam is associated with an increased risk of spina bifida if taken during pregnancy.

This answer is incorrect.

The statement, "Diazepam is associated with an increased risk of spina bifida if taken during pregnancy." is false.
Diazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is metabolized primarily in the liver, is approved as adjunct therapy only, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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C) Clonazepam works via an unknown mechanism.

This answer is incorrect.

The statement, "Clonazepam works via an unknown mechanism." is false.
Clonazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatment of absence seizures, is indicated for treatment of atypical absence seizures, is indicated for treatment of atonic seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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D) Oxcarbazepine has no known significant drug interactions.

This answer is incorrect.

The statement, "Oxcarbazepine has no known significant drug interactions." is false.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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E) Ethosuximide is a glutamate receptor antagonist.

This answer is incorrect.

The statement, "Ethosuximide is a glutamate receptor antagonist." is false.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0