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Antidepressant side effects 01

Topic: Pharmacology

Created on Sunday, December 30 2007 by jdmiles

Last modified on Sunday, December 30 2007.

A patient you see in clinic is suffering from major depression. You start him on an antidepressant. A week later, you receive a panic-stricken phone call from him. He complains that he has a painful erection that has persisted for the last 33 hours. Of the following medications, which is most likely to have caused this reaction?

A) Trazodone

B) Mirtazapine

C) Doxepin

D) Duloxetine

E) Venlafaxine

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This question was created on December 30, 2007 by jdmiles.
This question was last modified on December 30, 2007.

ANSWERS AND EXPLANATIONS

A) Trazodone

This answer is correct.

Priapism is a rare but well-known side effect of trazodone. (See References)


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B) mirtazapine

This answer is incorrect.

Mirtazapine is not associated with priapism. (See References)


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C) doxepin

This answer is incorrect.

Tricyclic and tetracyclic antidepressants, like amitriptyline, imipramine, doxepin, nortriptyline, and desipramine are associated with sexual side effects, but not with priapism. (See References)


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D) Duloxetine

This answer is incorrect.

Duloxetine appears to cause some sexual dysfunction, but is not associated with priapsim. (See References)


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E) venlafaxine

This answer is incorrect.

Venlafaxine is known to cause sexual dysfunction, but is not associated with priapism. (See References)


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References:

1. Warner, M.D., Peabody, C.A., Whiteford, H.A., and Hollister, L.E. (1987). "Trazodone and priapism." J Clin Psychiatry, 48(6) 244-5. (PMID:3584080)
2. Khawam, E.A., Laurencic, G., and Malone, D.A. (2006). "Side effects of antidepressants: an overview." Cleve Clin J Med, 73(4) 351-3, 356-61. (PMID:16610395)


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pharmacology
Antidepressant side effects 01
Question ID: 123007142
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/30/2007
Modified: 12/30/2007
Estimated Permutations: 4200