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Treatment of Guillain-Barre Syndrome 01

Topic: Adult

Created on Friday, October 3 2008 by jdmiles

Last modified on Friday, October 3 2008.

A patient presents with a 2 day history of worsening symmetric weakness. He states that the weakness began in the lower extremities, and now involves the upper extremities as well. Exam is normal except for notably decreased strength throughout, and absent reflexes. CSF is colorless, and shows no cells, elevated protein, and normal glucose.
You decide to initiate treatment.
Of the following options, which statement regarding treatment of this patient's disorder is most accurate?

 
        A) Plasmapheresis is more effective than IVIG, and there is no significant difference in side effects
 
        B) IVIG and Plasmapheresis are equally effective, but plasmapheresis has fewer side effects.
 
        C) IVIG is more effective than corticosteroids.
 
        D) IVIG is more effective than plasmapheresis, but has more side effects
 
        E) IVIG and Plasmapheresis are equally effective, and there is no significant difference in side effects.
 

 


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This question was created on October 03, 2008 by jdmiles.
This question was last modified on October 03, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Plasmapheresis is more effective than IVIG, and there is no significant difference in side effects

This answer is incorrect.


The patient has Guillain-Barre syndrome (GBS). In the treatment of GBS, IVIG and plasmapheresis are both more effective than corticosteroids. There is no clear difference in efficacy between IVIG and plasmapheresis, but IVIG has fewer side effects.  (See References)

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B) IVIG and Plasmapheresis are equally effective, but plasmapheresis has fewer side effects.

This answer is incorrect.


The patient has Guillain-Barre syndrome (GBS). In the treatment of GBS, IVIG and plasmapheresis are both more effective than corticosteroids. There is no clear difference in efficacy between IVIG and plasmapheresis, but IVIG has fewer side effects.  (See References)

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C) IVIG is more effective than corticosteroids.

This answer is correct.


The patient has Guillain-Barre syndrome (GBS). In the treatment of GBS, IVIG and plasmapheresis are both more effective than corticosteroids. There is no clear difference in efficacy between IVIG and plasmapheresis, but IVIG has fewer side effects.  (See References)

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D) IVIG is more effective than plasmapheresis, but has more side effects

This answer is incorrect.


The patient has Guillain-Barre syndrome (GBS). In the treatment of GBS, IVIG and plasmapheresis are both more effective than corticosteroids. There is no clear difference in efficacy between IVIG and plasmapheresis, but IVIG has fewer side effects.  (See References)

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E) IVIG and Plasmapheresis are equally effective, and there is no significant difference in side effects.

This answer is incorrect.


The patient has Guillain-Barre syndrome (GBS). In the treatment of GBS, IVIG and plasmapheresis are both more effective than corticosteroids. There is no clear difference in efficacy between IVIG and plasmapheresis, but IVIG has fewer side effects.  (See References)

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References:

1. Winer, J.B. (2002). "Treatment of Guillain-Barré syndrome." QJM, 95(11) 717-21. (PMID:12391383)
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adult
Treatment of Guillain-Barre Syndrome 01
Question ID: 100308124
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 10/03/2008
Modified: 10/03/2008
Estimated Permutations: 75600

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