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Demyelinating Diseases 02

Topic: Adult

Created on Tuesday, November 4 2008 by jdmiles

Last modified on Tuesday, November 4 2008.

Which of the following genes is associated with an increased risk of developing multiple sclerosis?

 
        A) BRCA1
 
        B) Sclerosin
 
        C) HLA DAZ7
 
        D) JRG10
 
        E) HLA DR2
 

 


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This question was created on November 04, 2008 by jdmiles.
This question was last modified on November 04, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) BRCA1

This answer is incorrect.


The human leukocyte antigen (HLA) DR2 allele has been shown to be associated with an increased risk in developing MS.  (See References)

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B) Sclerosin

This answer is incorrect.


The human leukocyte antigen (HLA) DR2 allele has been shown to be associated with an increased risk in developing MS.  (See References)

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C) HLA DAZ7

This answer is incorrect.


The human leukocyte antigen (HLA) DR2 allele has been shown to be associated with an increased risk in developing MS.  (See References)

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D) JRG10

This answer is incorrect.


The human leukocyte antigen (HLA) DR2 allele has been shown to be associated with an increased risk in developing MS.  (See References)

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E) HLA DR2

This answer is correct.


The human leukocyte antigen (HLA) DR2 allele has been shown to be associated with an increased risk in developing MS. HLA DR2 is also known as HLA DRB1*1501-DQB1*0602.  (See References)

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References:

1. Kalman, B., and Lublin, F.D. (1999). "The genetics of multiple sclerosis. A review." Biomed Pharmacother, 53(8) 358-70. (PMID:10554670)
2. Online Mendelian Inheritance in Man Database (OMIM:126200).Link to
OMIM DATABASE
3. Barcellos, L.F., Oksenberg, J.R., Begovich, A.B., Martin, E.R., Schmidt, S., Vittinghoff, E., Goodin, D.S., Pelletier, D., Lincoln, R.R., Bucher, P., Swerdlin, A., Pericak-Vance, M.A., Haines, J.L., and Hauser, S.L. (2003). "HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course." Am J Hum Genet, 72(3) 710-6. (PMID:12557126)
4. Zipp, F., Weber, F., Huber, S., Sotgiu, S., Czlonkowska, A., Holler, E., Albert, E., Weiss, E.H., Wekerle, H., and Hohlfeld, R. (1995). "Genetic control of multiple sclerosis: increased production of lymphotoxin and tumor necrosis factor-alpha by HLA-DR2+ T cells." Ann Neurol, 38(5) 723-30. (PMID:7486863)
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adult
Demyelinating Diseases 02
Question ID: 110408077
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 11/04/2008
Modified: 11/04/2008
Estimated Permutations: 25200

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