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Inclusionology 01

Topic: Anatomy

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Courtesy of Dr. Mark Cohen

Which of the following proteins is present in greatest abundance in this cytoplasmic inclusion?

 
        A) TDP-43
 
        B) Beta-amyloid
 
        C) Huntingtin
 
        D) Tau
 
        E) Alpha-synuclein
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) TDP-43

This answer is incorrect.


TDP-43 is the major protein component in the cytoplasmic inclusions of ALS  (See References)

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B) beta-amyloid

This answer is incorrect.


Amyloid is, by definition, extracellular, and is characteristically seen in Alzheimer disease and "pathologic aging".  (See References)

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C) Huntingtin

This answer is incorrect.


With immunohistochemical staining, intranuclear huntingtin can be demonstrated within neurons in Huntington disease  (See References)

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D) Tau

This answer is incorrect.


Paired helical filament tau protein is the major component of neurofibrillary tangles, dystrophic neurites, and neuropil threads  (See References)

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E) alpha-synuclein

This answer is correct.


Genetic analysis of the first large Parkinson disease pedigree demonstrated mutation in the alpha-synuclein gene. Subsequent biochemical analyses have shown this protein comprises the bulk of Lewy bodies and glial cytoplasmic inclusions (the latter in multiple system atrophy).  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)Advertising:
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anatomy
Inclusionology 01
Question ID: 020809050
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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