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Zoe MCQ 01

Topic: Anatomy

Created on Saturday, November 26 2022 by zoe

Last modified on Saturday, November 26 2022.

Ms. Neuron was recently prescribed a benzodiazepine for depression resulting in more Cl- conductance of the GABA receptor channel. This is an example of:

A) EPSPs: hyperpolarizing response moves the membrane away from the threshold

B) EPSPs: depolarizing response moves the membrane away from the threshold

C) IPSPs: depolarizing response moves the membrane away from the threshold

D) IPSPs: hyperpolarizing response moves the membrane away from the threshold

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This question was created on November 26, 2022 by zoe.
This question was last modified on November 26, 2022.

ANSWERS AND EXPLANATIONS

A) EPSPs: hyperpolarizing response moves the membrane away from the threshold

This answer is incorrect.

EPSPs create a more positive membrane potential (depolarizing). (See References)

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B) EPSPs: depolarizing response moves the membrane away from the threshold

This answer is incorrect.

Although EPSPs do create a more positive membrane potential (depolarizing), in this case, the benzodiazepine results in more Cl- conductance of the GABA receptor channel. EPSPs are usually the result of more Na+ or Ca++ ions. (See References)

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C) IPSPs: depolarizing response moves the membrane away from the threshold

This answer is incorrect.

Inhibitory post-synaptic potentials (IPSPs) creates a more negative membrane potential (hyperpolarizing), while EPSPs create a more positive membrane potential (depolarizing). (See References)

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D) IPSPs: hyperpolarizing response moves the membrane away from the threshold

This answer is correct.

Inhibitory post-synaptic potentials (IPSPs) creates a more negative membrane potential (hyperpolarizing). Benzodiazepines, in this case, open channels selective for Cl- and moves the membrane potential toward the Cl- equilibrium potential. This is the most common basis of fast IPSPs in the central nervous system. (See References)

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References:

1. Nolte: Chapter 8
2. Cell Physiology Source Book (Fourth Edition) 2012

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anatomy
Zoe MCQ 01
Question ID: 112622073
Question written by zoe. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 11/26/2022
Modified: 11/26/2022
Estimated Permutations: 24

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Zoe MCQ 01

Topic: Anatomy

ANSWERS AND EXPLANATIONS

A) EPSPs: hyperpolarizing response moves the membrane away from the threshold This answer is incorrect.

B) EPSPs: depolarizing response moves the membrane away from the threshold This answer is incorrect.