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Gliomas 01

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Courtesy of Dr. Mark Cohen

Which of the following molecular alterations is most commonly seen in this neoplasm?

 
        A) EGFR amplification
 
        B) P53 mutation
 
        C) 1p deletion
 
        D) Isochrome 17q
 
        E) INI 1 mutation
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) EGFR amplification

This answer is correct.


EGFR amplification is one of the most common molecular alterations seen in glioblastoma, and is particularly characteristic of the small cell type of GBM pictured here.  (See References)

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B) p53 mutation

This answer is incorrect.


Though commonly seen in glioblastomas (particularly those occuring in younger patients, p53 mutations are not characteristic of small cell GBMs  (See References)

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C) 1p deletion

This answer is incorrect.


1p deletion is characteristically seen in oligodendrogliomas, where it portends less aggressive behavior  (See References)

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D) isochrome 17q

This answer is incorrect.


I17q is een in about 40% of medulloblastomas, and does not appear to influence tumor behavior  (See References)

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E) INI 1 mutation

This answer is incorrect.


INI 1 mutation is seen in rhabdoid tumors in the CNS and elsewhere in the body  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)Advertising:
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pathology
Gliomas 01
Question ID: 020809059
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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