Neuromuscular 02

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.

 
        A) Malignant hyperthermia
 
        B) Thymoma
 
        C) Cardiomegaly
 
        D) Cold-induced myotonia
 
        E) Myoclonic epilepsy
 

 

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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) malignant hyperthermia

This answer is correct.

Though absence of cores does not insure the absence of MH, presence of cores is associated with increased risk of MH. In a family without a known mutation, in vitro testing at a specialized center is recommended.  (See References)

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B) thymoma

This answer is incorrect.

Thymoma may be associated with myasthenia gravis, which shows no abnormalities on NADH staining.  (See References)

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C) cardiomegaly

This answer is incorrect.

Cardiomegaly may be seen with lysososmal glycogen storage, which would show up most prominantly on PAS and acid phosphatase stains  (See References)

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D) cold-induced myotonia

This answer is incorrect.

The (non-dystrophic) channelopathies generally show no structural abnormalities on histochemical stains  (See References)

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E) myoclonic epilepsy

This answer is incorrect.

Patients with MERRF demonstrate subsarcolemmal accumulations of NADH(TR) positive mitochondria  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)

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pathology
Neuromuscular 02
Question ID: 020809061
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120