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Neuromuscular 02

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Courtesy of Dr. Mark Cohen

Patients with this pattern of staining on NADH(TR) are at increased risk for:

 
        A) Myoclonic epilepsy
 
        B) Malignant hyperthermia
 
        C) Cold-induced myotonia
 
        D) Cardiomegaly
 
        E) Thymoma
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) myoclonic epilepsy

This answer is incorrect.


Patients with MERRF demonstrate subsarcolemmal accumulations of NADH(TR) positive mitochondria  (See References)

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B) malignant hyperthermia

This answer is correct.


Though absence of cores does not insure the absence of MH, presence of cores is associated with increased risk of MH. In a family without a known mutation, in vitro testing at a specialized center is recommended.  (See References)

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C) cold-induced myotonia

This answer is incorrect.


The (non-dystrophic) channelopathies generally show no structural abnormalities on histochemical stains  (See References)

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D) cardiomegaly

This answer is incorrect.


Cardiomegaly may be seen with lysososmal glycogen storage, which would show up most prominantly on PAS and acid phosphatase stains  (See References)

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E) thymoma

This answer is incorrect.


Thymoma may be associated with myasthenia gravis, which shows no abnormalities on NADH staining.  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)Advertising:
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pathology
Neuromuscular 02
Question ID: 020809061
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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