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Neuromuscular 01

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Ultrastructurally, these cytoplasmic inclusions most closely resemble:

 
        A) Z-bands
 
        B) Actin filaments
 
        C) Mitochondria
 
        D) Sarcoplasmic reticulin
 
        E) Myosin filaments
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Z-bands

This answer is correct.


Nemaline rods appear to composed predominantly of alpha-actinin, and resemble z-bands  (See References)

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B) actin filaments

This answer is incorrect.


Amyloid filaments are 8-9nm in diameter, and hence may resemble thin actin filaments  (See References)

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C) mitochondria

This answer is incorrect.


Mitochondria appear redder on trichrome, and are preferentially seen in subsarcolemmal locations  (See References)

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D) sarcoplasmic reticulin

This answer is incorrect.


Tubular aggregates reseble sarcoplasmic reticulin, and appear as bright red subsarcolemmal aggregates on trichrome staining  (See References)

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E) myosin filaments

This answer is incorrect.


Tubulofilamentous inclusions (characteristic of inclusion body myositis) are even somewhat larger than the thick myosin filaments  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)Advertising:
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pathology
Neuromuscular 01
Question ID: 020809068
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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