Last modified on Sunday, February 8 2009.
Courtesy of Dr. Mark Cohen
This 42-year old former all-American quarterback comes in complaining of slowly progressive lower extremity weakness which began just after he got married 15 years ago. Which of the following diagnoses is most likely correct?
Dysferlin is responsible for repairing membrane defects, and dysferlinopathy usually presents in early adulthood. The presence of inflammation may mislead one into a diagnosis of inflammatory myopathy (
Though the distribution of inflammation is OK, the infiltrate in DM is composed of a mixture of lymphocytes, plasma cells, and occasional eosinophils. (
FSH dystrophy may be accompanied by inflammation, but shows a different pattern of weakness (