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Myelin 02

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Courtesy of Dr. Mark Cohen

In the absence of inflammation, this pattern on myelin loss is characteristic of which of the following?

 
        A) Acute disseminated encephalomyelitis
 
        B) Disseminated necrotizing leukoencephalopathy
 
        C) Cockayne disease
 
        D) Pelizaeus-Merzbacher disease
 
        E) Grinker myelinopathy (CO intoxication)
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Acute disseminated encephalomyelitis

This answer is incorrect.


Perivascular myelin loss defines this entity, but requires concomittant perivascular lymphocytic inflammation  (See References)

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B) Disseminated necrotizing leukoencephalopathy

This answer is incorrect.


Disseminated necrotizing leukoencephalopathy affects deep white matter and brainstem tegmentum without perivascular accentuation  (See References)

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C) Cockayne disease

This answer is incorrect.


Cockayne disease is characterised by perivascular SPARING of myelin, accompanied by basal ganglia calcifications and leptomeningeal fibrosis.  (See References)

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D) Pelizaeus-Merzbacher disease

This answer is incorrect.


Pelizaeus-Merzbacher disease is characterised by perivascular SPARING of myelin  (See References)

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E) Grinker myelinopathy (CO intoxication)

This answer is correct.


Non-inflammatory perivascular myelin loss is characteristic of delayed carbon monoxide neurotoxicity  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)Advertising:
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pathology
Myelin 02
Question ID: 020809105
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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