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Infections 09

Topic: Pathology

Created on Friday, February 13 2009 by gliageek

Last modified on Friday, February 13 2009.


Courtesy of Dr. Mark Cohen
Which of the following cell types is primarily infected in this viral infection?

 
        A) Endothelial cells
 
        B) Neurons
 
        C) Oligodendroglia
 
        D) Microglial cell
 
        E) Astrocytes
 

 


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This question was created on February 13, 2009 by gliageek.
This question was last modified on February 13, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Endothelial cells

This answer is incorrect.


Though transversed by infected mononuclear cells, endothelial cells are not infected by HIV.  (See References)

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B) Neurons

This answer is incorrect.


The HIV virus may cause morbidity through surface interactions with neurons, but does not productively infect them  (See References)

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C) Oligodendroglia

This answer is incorrect.


Oligodendroglial cells may be damaged by TNF and other cytokines secreted by HIV infected microglial cells, but are not themselves infected.  (See References)

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D) Microglial cell

This answer is correct.


Virally infected monocytes cross the BBB and fuse with microglial cells, resulting in the pathognomonic multinucleate microglial cells. Cytokine production from these cells causes morbidity resulting in HIV encephalopathy.  (See References)

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E) Astrocytes

This answer is incorrect.


Though astrocytes may be infected in some artificial culture conditions, there is no evidence for astrocyte infection in vivo  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)Advertising:
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pathology
Infections 09
Question ID: 021309170
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/13/2009
Modified: 02/13/2009
Estimated Permutations: 120

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