Have you seen the parietal watch?

Neuromuscular 06

Topic: Pathology

Created on Saturday, February 14 2009 by gliageek

Last modified on Saturday, February 14 2009.


Courtesy of Dr. Mark Cohen
This NADH-TR stained muscle shows features most consistent with:

 
        A) Inclusion bodies
 
        B) Plaquenil myopathy
 
        C) Acid maltase deficiency
 
        D) Reinnervation
 
        E) Rhabdomyolysis
 

 


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This question was created on February 14, 2009 by gliageek.
This question was last modified on February 14, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Inclusion bodies

This answer is incorrect.


These show central clearing with surrounding granular material, best seen on H&E and trichrome  (See References)

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B) Plaquenil myopathy

This answer is incorrect.


Choloroquine & hydroxychloroquine myopathy demonstrates multiple smaller vaculoles within muscle fibers, representing dilated lysosomes  (See References)

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C) Acid maltase deficiency

This answer is incorrect.


Lysosomal glycogen storage does not show peripheral increase in NADH-TR staining  (See References)

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D) Reinnervation

This answer is correct.


As atrophied fibers replenish contractile elements after reinnervated, central areas are initially devoid of mitochondria, sarcoplasmic reticulin and ATPase, known as target fibers  (See References)

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E) Rhabdomyolysis

This answer is incorrect.


Moth-eaten fibers may be seen in some cases of rhabdomyolysis  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)Advertising:
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pathology
Neuromuscular 06
Question ID: 021409127
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/14/2009
Modified: 02/14/2009
Estimated Permutations: 120

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