The FrontalCortex question bank is free for everyone, everywhere.

Myelin 03

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.


Courtesy of Dr. Mark Cohen
The large cells within the photograph result from:

 
        A) Accumulation of sulfatide
 
        B) Accumulation of globotriaosylceramide
 
        C) Accumulation of galactosylceramide
 
        D) Deficiency in sphingomyelinase
 
        E) Accumulation of spingolipid ceramide
 

 


Back to the question = Go back to the top of the page.
See another question like this one = Reload a different version of this question ().
Click here for a random question = Load a random question from the database.
Clone this question = Use this question as a template to create a totally NEW question.
Rate this question = Enter detailed rating for this question!
Average user rating for this question = 4 = How users like you have rated this question.
This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Accumulation of sulfatide

This answer is incorrect.


Metachromatic leukodystrophy  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




B) Accumulation of globotriaosylceramide

This answer is incorrect.


Fabry's disease, with accumulation of globotriaosylceramide within endothelial cellsA  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




C) Accumulation of galactosylceramide

This answer is correct.


Deficiency of galatocerebroside B-galactosidase results in the accumulation of the toxic intermediate galactosylceramide ("psychosine") via an alternate catabolic pathway  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




D) Deficiency in sphingomyelinase

This answer is incorrect.


Foam cell infiltration in PNS and viscera (Niemann-Pick disease)  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




E) Accumulation of spingolipid ceramide

This answer is incorrect.


Spingolipid ceramide may accumulate in Schwann cells in Farber disease  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4
Please log in if you want to rate questions.

 

 

 

 

References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)Advertising:
Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4
Please log in if you want to rate questions.

 

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
pathology
Myelin 03
Question ID: 021509085
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120

User Comments About This Question:

0 user entries
Please log in if you'd like to add a comment.