Myelin 07

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.

 
        A) Manganese
 
        B) Carbon monoxide
 
        C) Inorganic lead
 
        D) Methyl mercury
 
        E) Methotrexate
 

 

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This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Manganese

This answer is incorrect.

Selective neuronal loss involving basal ganglia  (See References)

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B) Carbon monoxide

This answer is incorrect.

Perivenous myelin loss without inflammation of axonal swellings ("Grinker myelinopathy").  (See References)

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C) Inorganic lead

This answer is incorrect.

Cerebral edema, particularly of cerebellum, vascular proliferation, and petechial hemorrhages  (See References)

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D) Methyl mercury

This answer is incorrect.

Damage to cerebral and cerebellar neurons  (See References)

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E) Methotrexate

This answer is correct.

Methotrexate neurotoxicity is characterized by disseminated necrotizing leukoencephalopathy with axonal swellings.  (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Myelin 07
Question ID: 021509094
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120