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Myelin 07

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.


Courtesy of Dr. Mark Cohen
This form of leukoencephalopathy is most closely associated with which of the following agents?

 
        A) Manganese
 
        B) Methyl mercury
 
        C) Inorganic lead
 
        D) Carbon monoxide
 
        E) Methotrexate
 

 


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This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Manganese

This answer is incorrect.


Selective neuronal loss involving basal ganglia  (See References)

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B) Methyl mercury

This answer is incorrect.


Damage to cerebral and cerebellar neurons  (See References)

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C) Inorganic lead

This answer is incorrect.


Cerebral edema, particularly of cerebellum, vascular proliferation, and petechial hemorrhages  (See References)

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D) Carbon monoxide

This answer is incorrect.


Perivenous myelin loss without inflammation of axonal swellings ("Grinker myelinopathy").  (See References)

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E) Methotrexate

This answer is correct.


Methotrexate neurotoxicity is characterized by disseminated necrotizing leukoencephalopathy with axonal swellings.  (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)Advertising:
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pathology
Myelin 07
Question ID: 021509094
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120

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